A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Longterm adverse effects of paracetamol a review McCrae 2018 British Journal of Clinical Pharmacology Wiley Online Library Molecular Modelling Analysis of the Metabolism of Paracetamol Paracetamol NAPQI Wikipedia Acetaminophen metabolism
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paracetamol and glutathione depletion Paracetamol toxicity - Biochemical Basis