Laser Lip Treatment for Lip Discoloration: Patient Transformation What Caused These Multiple Hyperpigmented Macules of the Mouth? Pigmented Lesions Pocket Dentistry Dark Spot on Lip: Harmless or Serious? What to Check First La Bouche Parfaite Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.