DNA Methylation Defined The methylation cycle and glutathione synthesis pathway. Metabolites Download Scientific Diagram Methylation DNAlysis Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism The American Journal of Clinical Nutrition When people think about detox, they usually think about the liver. But detoxification actually involves several systems working together. One of the most important is methylation. Methylation supports processes involved in Estrogen Metabolism, Detoxification, and Methylation Dr. Daniel Metzger, DACM, L.Ac.