Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Man Concerned About a New Spot On His Lip Let's Diagnose VisualDx Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Taint melanotic of the lip vaporization laser UNILASER MDICA Pigmented Lesions Pocket Dentistry