Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Paracetamol is one of the most commonly used analgesic and antipyretic drugs. Paracetamol poisoning ml nyein PPTX Acetaminophen toxicity EMCrit Project Acetaminophen Pathway (toxic doses), Pharmacokinetics Paracetamol Glutathione