MTHFR Mutation? Start Here to Learn! Seeking Health MTHFR, Hashimoto's, and Nutrients Dr. Izabella Wentz Who is this MTHFR gene mutation and why is it more common than you think? Up to 60% of the population carries a mutation in the MTHFR gene, which plays a 7 Health Tips for People with MTHFR Mutations MTHFR Gene Mutation and Enzyme Activity At Home Health Tests The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.