OTC, NOT RISK FREE: We're getting more calls than usual about acetaminophen, the active ingredient in Tylenol. Many over the counter (OTC) products contain a mix of pain and fever reducers, cough suppressants, and other Mechanistic insights into hepatic cell type specific contributions to acetaminophen induced acute liver injury Coptidis Rhizoma Alkaloids Alleviate Acetaminophen Induced Liver Injury by Regulating GSH Metabolism and the TNF Signaling Pathway Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library Metabolic activation pathway of acetaminophen. Generally, NAPQI is Download Scientific Diagram Targeting gut microbiota to counteract acetaminophen induced acute liver injury: Trends in Microbiology