GHK Cu is a naturally occurring tripeptide in human plasma. Levels average 200 ng ml at age 20 and drop to 80 ng ml by age 60 (Pickart et al., 2020). That decline tracks with Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts Jeffrey D. Pollard, Susan Quan, Thomas Kang, R. James Koch, 2005 Growth Hormone and Aging Endotext NCBI Bookshelf Relief of ovalbumin induced airway remodeling by the glycyl l histidyl l lysine Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cells ScienceDirect How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Does GHK Cu Really Work? 40 Years of Research Reviewed