Paracetamol (Acetaminophen) hepatotoxicity and its management. Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Tylenol And Glutathione Invigor Medical Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.