FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology FOXO4 DRI alleviates age related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging FOXO4 DRI Anti Aging: Approach to Cellular Rejuvenation Mokiner Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway A biological miracle is happening in anti aging where the body takes out the trash. The peptide reduced frailty markers by 50% in aged mice, inducing apoptosis (death) only in damaged cells. It The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity.