Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. IRE1 determines ferroptosis sensitivity through regulation of glutathione synthesis Nature Communications Mast Cell Activation Syndrome (MCAS) Mast Cell Activation Syndrome San Diego Naturopathic Doctor & IV Therapy MCAS and Quercetin Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review