Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library Taking Tylenol? The Glutathione Connection Dr. Green Mom Your livers unsung hero: Glutathione , Lets talk about what really happens when you take Tylenol (acetaminophen)., Your liver breaks down acetaminophen through several pathways. One pathway creates Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports