Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library