Dark Spot on Lip: Harmless or Serious? What to Check First La Bouche Parfaite Pathology Outlines Melanotic macule Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Spot the Dot! Growths on the lips are not too common. Clinically, this was consistent with a labial melanotic macule (aka freckle on the lip). These are benign growths which can be In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Mucosal melanocytic macules