Glutathione, Alcohol and drugs Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Can paracetamol (acetaminophen) be administered to patients with liver impairment? Hayward 2016 British Journal of Clinical Pharmacology Wiley Online Library A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health